Surgery can be done when pharmacological treatment is not effective, and the most common procedure is Nissen fundoplication, where the gastric fundus is wrapped around the lower esophageal sphincter in order to make it tighter.

当药物治疗无效时，可以进行手术，最常见的手术方法是Nissen胃底折叠术，指胃底包裹在食管下括约肌周围以使其更紧。