Its ugly and spiteful little din (heard now for the first time, perhaps, since Hepzibah's periwigged predecessor had retired from trade) at once set every nerve of her body in responsive and tumultuous vibration.

它丑陋而恶毒的小喧闹声（现在可能是第一次听到， 因为 Hepzibah 戴假发的前任已经退出贸易）立即让她身体的每一根神经都在响应和混乱的震动中。