First, the osteocytes release chemical signals that direct osteoclasts to the site of the damage.

首先，骨细胞释放化学信号，将破骨细胞引导到损伤部位。

Osteoclasts break down the unneeded mineral lattice using acids and enzymes so that osteoblasts can then add more material.

破骨细胞以酸和酵素酶 将无用的矿物晶格拆解这样就可以提供 更多原料给造骨细胞。

It does this by stimulating osteoclasts, the cells that break bone down, to release hydrogen ions which dissolves the hard, mineralized hydroxyapatite.

甲状旁腺激素通过刺激破骨细胞来释放氢离子；破骨细胞是一种分解骨骼的细胞，可溶解坚硬的矿化羟基磷灰石。

They're like the construction foremen of your bones, passing along commands to your skeleton's two main workhorses: the osteoblasts and the osteoclasts.

它们就像你骨骼的建筑工头，将命令传递给你骨骼的两个主要主力：成骨细胞和破骨细胞。

Throughout your life, your bones are broken down by large cells called osteoclasts, releasing calcium into the bloodstream.

在您的一生中， 您的骨骼会被称为破骨细胞的大细胞分解，从而将钙释放到血液中。

When the old bone tissue is cleaned out, the osteoclasts then undergo apoptosis, where they basically self-destruct before they can do any more damage.

当旧的骨组织被清除后，破骨细胞会发生凋亡，在造成更多伤害之前，它们基本上会自毁。

And finally we got an introduction to the process of bone remodeling, which is carried out by crews of osteocytes, osteoblasts, and osteoclasts.

最后，我们得到了骨骼重塑过程的介绍，这是由骨细胞、成骨细胞和破骨细胞团队进行的。

Now, even though parathyroid hormone stimulates bone resorption, it's been found that intermittent injections with teriparatide activates osteoblasts more than osteoclasts, therefore increasing bone formation.

其实，即使甲状旁腺激素刺激骨吸收，研究发现间歇性注射特立帕肽激活了更多造骨细胞而非破骨细胞，从而增强骨生长。

Ok, now, when osteoclasts break down bone faster than the osteoblasts can rebuild it, it results in the lowering of the bone mass and eventually in osteoporosis.

那么，当破骨细胞分解骨骼的速度比造骨细胞重建骨骼更快时，骨量就会减少，最终导致骨质疏松。

Because your immune system rushes to the rescue, sending in special cells called osteoclasts, which ultimately relieve the pressure and restore blood flow.

因为您的免疫系统会迅速进行救援，派遣称为破骨细胞的特殊细胞，最终缓解压力并恢复血液流动。

Finally, medications like denosumab, which is a monoclonal antibody that inhibits osteoclasts, and raloxifene, which is a selective estrogen receptor modulator, can be used for postmenopausal osteoporosis.

最后，地诺单抗等药物作为单克隆抗体可抑制破骨细胞；雷洛昔芬，一种有选择性的雌激素受体调节器，可以被用于绝经后骨质疏松。

With senile osteoporosis, on the other hand, it's believed that osteoblasts just gradually lose the ability to form bone, while the osteoclasts keep doing their thing unabated.

另一方面，老年性骨质疏松被认为是由于造骨细胞逐渐失去造骨的能力，同时破骨细胞持续工作，活力不减。

So while your osteoblasts are the bone-makers, your osteoclasts are the bone-breakers — which is a kind of violent image. Maybe think of them as like a bone-breaker-downer.

所以当你的成骨细胞是骨骼制造者，你的破骨细胞是骨骼破坏者——这是一种暴力的形象。也许可以把它们想象成一个碎骨剂。

But, for reasons that we don't understand yet, the osteoclasts actually increase their rate of bone resorption in low gravity, while the osteoblasts dial back on the bone formation.

但是，由于我们还不明白的原因，破骨细胞实际上在低重力下增加了骨吸收的速度，而成骨细胞则减少了骨的形成。

The tumor cells arises from osteoclasts cells, but then develop into cells that have numerous nuclei - typically over 50 nuclei - so you can think of them as destructive little giants.

这些肿瘤细胞起源于破骨细胞，但随后发展为多核细胞，通常超过50个细胞核，因此你可以将他们视为具有破坏性的小巨核。