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单词 misfolded
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The misfolded proteins and clumps may spread from cell to cell.

错误折叠的蛋白质和团块可能在细胞间传播。

Osmosis-神经

Normally, neurons contain a protein called alpha-synuclein, and in Lewy body dementia, this protein gets misfolded within the neurons.

正常情况下,神经元中含有一种叫作α-突触核蛋白的蛋白质;在路易体痴呆中,这种蛋白质在神经元中错误地折叠。

Osmosis-神经

The misfolded alpha-synuclein aggregates to form Lewy bodies that deposit inside neurons, particularly in the cortex and the substantia nigra.

错误折叠的α-突触核蛋白聚集形成路易小体,沉积在神经元中,尤其是在皮层和黑质中。

自然杂志:人体健康

Another problem seen in animal models is that misfolded Tau proteins can spread, across synapses, into healthy neurons.

在动物模型中发现的另一个问题是错误折叠的 Tau 蛋白可以通过突触扩散到健康的神经元中。

Osmosis-心血管

Familial amyloid cardiomyopathy is a genetic disorder where mutant transthyretin protein, or TTR, is misfolded and prone to depositing in the heart tissue.

家族性淀粉样心肌病是一种基因疾病:突变的转甲状腺素蛋白(TTR)折叠错误,并易于在心脏组织中沉积。

Osmosis-心血管

Amyloids are proteins that have been misfolded, and once misfolded they become insoluble and can deposit in various tissues and organs, making them less compliant.

淀粉样蛋白是错误折叠的蛋白质,一旦折叠错误,它们就变得不可溶;这些蛋白可以沉积在很多的组织和器官当中,让其顺应性变差。

读者文摘选编

Researchers theorize that the misfolded protein sometimes travels up the vagus nerve to the brain, where it can affect cells involved with movement, causing the tremors that are a hallmark of Parkinson's.

研究人员推测,这种错误折叠的蛋白质有时会通过交感神经到达大脑,它可以影响与运动有关的细胞,引起震颤,这是帕金森氏症的一个特征。

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