Not at all, it really made a lot of difference.

是真的，差别真的很大。

Not at all. It really made a lot of difference.

当然不是。真的有区别。

We think these new traffic regulations would make a lot of difference.

我们觉得这些新的交通规章制度会带来很大的影响。

Writing is a lonely job. Having someone who believes in you makes a lot of difference.

写作是一种孤单的工作。有人相信你对你至关重要。

If you had to point to one reform that could make a lot of difference, what would that be?

如果你要指出一项会造成很大不同的改革，你认为是哪个？

Of course, extreme circumstances make a lot of difference, whether we're living in a free country versus oppression. That makes a lot of difference.

当然了，外部环境很重要，我们生活在一个自由的国度，还是受人压迫，带来的结果是完全不同的。

It don't make a lot of difference any more now though.

虽然现在已经没有太大区别了。