A large angiomyolipoma can cause flank pain, a lymphangioleiomyomatosis in the lungs, can cause shortness of breath, and a retinal hamartoma can cause vision changes.

巨大的血管平滑肌脂肪瘤可引起腹痛；肺淋巴管平滑肌瘤可引起呼吸短促；视网膜错构瘤会导致视力改变。

Individuals can also have lymphangioleiomyomatosis in the lungs, which are cysts where the normal lung tissue is gradually replaced by cysts lined by endothelial cells, which are the cells that normally line the blood vessels.

患者也可能出现肺淋巴管平滑肌瘤，即正常的肺组织逐渐被内皮细胞所覆盖的囊肿所取代；正常情况下，这些内皮细胞应该待在血管壁上。