On the first, we've seen a sea change in public perception.

首先，我们看到，公众观念已经发生了巨大的变化。

With the birth of Sean came a sea change in Lennon's life.

肖恩的降生让列侬的生活发生了翻天覆地的变化。

With this signing, we mark more than just an agreement. We mark a sea change in international trade.

这场签字仪式标志的不仅仅是一项协议。还标志着国际贸易的重大变化。

But this comes amid really a sea change in the way physicians are prescribing opioids to begin with.

但这是医生在开阿片类药物处方方面巨大改变的开始。

Despite the small crowds, limited in size because of COVID-19, the event marked a sea change in political tone.

尽管由于新冠肺炎的影响，参加就职典礼的人数有限，但这一活动标志着政治基调发生了巨大变化。

" It is a sea change, " says Claire Guthrie Gastanaga, executive director of the American Civil Liberties Union of Virginia.

“这是一场翻天覆地的变化，”弗吉尼亚州美国公民自由联盟的执行董事克莱尔·格思里·加斯塔纳加说。

Creation is going through a sea change as the balance between consumption and creation changes.

随着消费和创造之间的平衡发生变化，创造正在经历翻天覆地的变化。

It wasn't a sea change in his expression, but a faint hardening, a lowering of his gaze.

他的表情并没有发生翻天覆地的变化， 而是微微的凝重，目光的垂下。

He said the latest results show there has been a " sea change" in the way the world deals with its ozone-thinning substances.

他说，最新的研究结果表明，世界在处理致使臭氧层变薄的物质的方式上发生了“翻天覆地的变化”。

And speaking of resolution: we'll be staying in France for one more episode, to take a look at a sea change in acting and the rise of the director.

我们将在法国再待一集 来看看演员们演技上的巨大变化以及导演行业的崛起。

So now that people understand the alignment in this,   in the positive social outcomes and that you can be pro-business, pro-environment,   pro people, it's really been a sea change.

所以现在人们明白了这方面的一致性，在积极的社会成果中，你可以成为有利于商业、有利于环境、有利于人民的人，这真的是一个翻天覆地的变化。

The move marked a sea change in NATO cyber strategy, and sparked questions about how best to bolster NATO cyber defenses — and if offense, of a sort, might be part of the solution, too.

此举标志着北约网络战略发生了翻天覆地的变化，并引发了关于如何最好地加强北约网络防御的问题——以及进攻，是否也可能成为解决方案的一部分。

It really is this idea of precision medicine, you know, not treating all patients the same, but treating their individual cancers based on really detailed analysis. And I think it really represents a sea change.

这确实是精准医学的理念，你知道，不是对所有患者都进行相同的治疗，而是根据非常详细的分析来治疗他们的个体癌症。我认为它确实代表了翻天覆地的变化。

But a recently published study of online research habits, conducted by scholars from University College London, suggests that we may well be in the midst of a sea change in the way we read and think.

伦敦大学学院的学者做了一个网络研读习惯的研究并发表了研究结果。该研究指出，我们可能已经彻底置身于阅读与思考方式的巨变之中了。

So how much of a sea change is this? I mean, when you think about - as we began this conversation, in my own head, I was thinking lung cancer, breast cancer, colon cancer, I mean, just like you said, right?

那么这是多大的翻天覆地的变化呢？我的意思是，当你想到 - 当我们开始这次谈话时，在我自己的脑海里，我在想肺癌，乳腺癌，结肠癌，我的意思是，就像你说的，对吗？