Oh, dear, sweet, sober Caroline Abbott has a screw loose!

哦，亲爱的，可爱的，清醒的 Caroline Abbott 有一个螺丝松了！

That ball of fluff got a screw loose.

这绒毛球疯了。

They always had a good time, and the bad boys had the broken legs; but in his case there was a screw loose somewhere, and it all happened just the other way.

他们总是玩得很开心， 坏男孩的腿断了；但是在他的情况下， 某个地方的螺丝松了， 一切都以相反的方式发生了。