In Zollinger-Ellison syndrome, a tumor called gastrinoma secretes large amount of gastrin, that stimulates hydrochloric acid secretion in excess, and makes reflux even worse.

在佐林格-埃利森综合征中，一种叫做胃泌素瘤的肿瘤分泌大量胃泌素，刺激盐酸分泌过多，使反流更加严重。