Causes of secondary amenorrhea can also cause primary amenorrhea, and they include functional hypothalamic amenorrhea, polycystic ovary syndrome, hyperprolactinemia, premature ovarian failure and Asherman syndrome.

继发性闭经的病因也可以导致原发性闭经，包括功能性下丘脑性闭经、多囊卵巢综合症、高泌乳素血症、卵巢早衰以及Asherman综合征。