Other research suggests that minimal change disease and FSGS have different mechanisms of podocyte injury.

而另一些研究表明微小病变性肾病和FSGS涉及的足细胞损伤机制有所不同。

Heroin abuse has also been linked to FSGS, which is called heroin nephropathy.

海洛因滥用也与FSGS有关，称为海洛因肾病。

HIV, a retrovirus that infects various human cell types, can lead to FSGS and is called HIV-associated nephropathy.

HIV，一种感染人类不同细胞的逆转录病毒，可能导致FSGS，称为HIV相关肾病。

Well, primary FSGS is when it's idiopathic, or there's no clear underlying cause.

原发性FSGS特发（于肾），即未明确潜在病因。

Those glomeruli that are affected, though, allow proteins to filter through into the urine, and ultimately people with FSGS develop nephrotic syndrome.

当这些肾小球受累，蛋白质可滤过入尿，最终，FSGS患者出现肾病综合征。

As opposed to primary FSGS, Secondary FSGS is when there's a clear underlying cause, and there are several important conditions that can be associated.

与原发性FSGS不同，继发性FSGS有其明确的病因，有几个病理过程可能与之有关。

Some research suggests that these changes in FSGS are a continuation from another nephrotic syndrome called minimal change disease which is also characterized by podocyte injury.

一些研究表明FSGS的病变是由另一种肾病综合征微小病变性肾病发展而来的；该病也是由足细胞损伤介导的。

Sickle cell disease, where blood cells are sickle-shaped due to a structurally abnormal hemoglobin protein that can cause tissue ischemia, has been linked to FSGS.

血细胞因血红蛋白结构异常而整体呈现镰刀形，可导致组织缺血，与FSGS有关。

Fundamentally, FSGS is a histopathologic description, basically what it looks like under a microscope, which could be the end result of a number of different pathophysiologic mechanisms.

从根本上讲，FSGS是组织学上的描述性病变，即反映其镜下特点，它可以是众多不同的（肾小球）病变的最终结果。

Also, other conditions like kidney hyperperfusion or increased perfusion of blood, as well as increased pressure in the glomerular capillaries have been linked to FSGS as well.

除此之外，肾高灌注或肾血流量增加等疾病以及肾毛细血管球内压力增高也与FSGS有关。

FSGS is usually treated with steroids, although it has an inconsistent response, and for that reason, especially in adults— FSGS can involve more and more segments of the kidney's glomeruli to the point where it causes chronic renal failure.

FSGS通常用类固醇治疗，不过治疗反应并不一致；因此，尤其在成人中，FSGS可累及越来越多肾小球的节段，直至慢性肾衰。