One cognitive disorder, fragile-X syndrome, is indeed much more common in men for this reason.

认知障碍，X染色体易损综合症，确实因为这个原因在男性中很常见。

Additionally, a karyotype can be done to look for chromosomal abnormalities and specific genetic tests can be ordered if there's a family history of Fragile-X syndrome.

此外，可进行核型分析以寻找染色体异常，如果有脆性X染色体综合征家族史，可以进行特定的基因检测。

Other times it can be a gene mutations, like BRCA1, or in a syndrome like Fragile X syndrome, which is caused by the expansion of a trinucleotide repeat within a gene on the X chromosome.

某些情况下可能是基因突变，如BRCA1；也可能是像脆性X染色体综合征这样的综合征，这是由于X染色体上某基因内的三核苷酸重复扩增引起的。