But when you add or subtract one or two nucleotides, it essentially shifts all the remaining nucleotides, usually ends up in totally different amino acids being coded, and probably a dysfunctional protein.

但当你向核苷酸序列中增加或减少一个或两个核苷酸时，基本上会使全部剩余的核苷酸序列发生移位，最终会编码完全不一样的氨基酸序列，或者是一种功能失调的蛋白质。