Prescribed medication is the next step if dietary modifications and vitamin B6 therapy with doxylamine are ineffective.

如果饮食疗法与联合应用维生素B6和抗敏安无效，下一步就需要开处方药。

"Mr.Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam, and doxylamine," the office said in a short statement.

主要意思是已经定论根据特征判断死亡是意外，由于处方药引起混合效应中毒。