During a flare, T-cells cause inflammation and damage to oligodendrocytes in the central nervous system, which leaves behind scarred areas of demyelinated neurons called plaques, which causes a variety of symptoms depending on the location.

在发作期间，T淋巴细胞导致炎症并损伤中枢神经系统的少突胶质细胞，在脱髓鞘神经元处形成瘢痕（硬化斑），从而根据部位的不同产生不同的症状。