They didn't know exactly how cyclopamine caused the defect but told ranchers to steer clear.

他们并不清楚环杷明是如何导致缺陷的，但告诉牧场工人让羊群避开这种植物。

Unfortunately, researchers eventually found that cyclopamine causes negative side effects, and its chemical properties make it difficult to work with.

不幸的是，研究者最终发现，环杷明会导致负面的副作用，并且它的化学性质让人们难以把握。

So even though the hedgehog protein is still doing its job of keeping the way clear for smoothened, cyclopamine blocks smoothened from passing along its chemical message.

因此，虽然刺猬蛋白仍在工作，帮助smoothened保持通路顺畅，环杷明阻挡了smoothened通过化学信息传递。